Lana Parrilla makes a very interesting point. IMO the canonicity of her statement is sketchy; this is more like her personal interpretation. However, it makes sense for Regina to have the same view. Perhaps this is a common belief in FTL. Regina believed she would never love again. Her supposed One True Love was taken from her and she would never have another chance with him. This fueled her hatred for Snow and eventually led to her downfall.

I wonder what would happen if Regina were proven wrong?